How is (2S,2'S)-2,2'-(1,2-Ethanediyldiimino)disuccinic acid (CAS: 20846-91-7) typically synthesized?

(2S,2'S)-2,2'-(1,2-Ethanediyldiimino)disuccinic acid can be synthesized through the condensation of diisuccinoyl chloride with ethylenediamine. This process involves the use of a condensation catalyst such as 4-dimethylaminopyridine (DMAP) or a base like triethylamine to enhance the reaction selectivity and yield. The reaction typically proceeds in an anhydrous organic solvent like dichloromethane or tetrahydrofuran at room temperature, resulting in a high yield of the desired product.