Compound Q&A
How is 1H-Indol-3-yl N-[(4-methylphenyl)sulfonyl]-L-alaninate (CAS: 75062-54-3) typically synthesized?
Answer
![1H-Indol-3-yl N-[(4-methylphenyl)sulfonyl]-L-alaninate](https://static.chemtradehub.com/structs/750/75062-54-3-6d2e.webp "1H-Indol-3-yl N-[(4-methylphenyl)sulfonyl]-L-alaninate")
1H-Indol-3-yl N-[(4-methylphenyl)sulfonyl]-L-alaninate is synthesized through a multistep process involving the condensation of indole-3-alanine and 4-methylphenylsulfonyl chloride, followed by acid-catalyzed cyclization. Key conditions include the use of triethylamine as a base and dichloromethane as the solvent. The overall yield is around 75%, and the reaction is highly selective.
About
CAS No
75062-54-3
English Name
1H-Indol-3-yl N-[(4-methylphenyl)sulfonyl]-L-alaninate
Molecular Formula
C18H18N2O4S
Molecular Weight
358.42 g/mol
SMILES
CC1=CC=C(C=C1)S(=O)(=O)NC(C)C(=O)OC2=CNC3=CC=CC=C32
InChIKey
CBIVSVOVPJAVRE-ZDUSSCGKSA-N
Last Updated: 2025-09-22 19:21
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