How is 2,4-Dichloro-5-nitropyrimidine (CAS: 49845-33-2) typically synthesized?

2,4-Dichloro-5-nitropyrimidine (CAS: 49845-33-2) is usually synthesized by the nitration of 2,4-dichloropyrimidine. The reaction is typically carried out using concentrated nitric acid under carefully controlled conditions. The process requires strict temperature and concentration control to achieve the desired yield and selectivity. The reaction mixture is then purified by recrystallization to obtain the pure compound.