Compound Q&A
How is Methyl 3-(trifluoromethyl)benzoate (CAS: 2557-13-3) typically synthesized?
Answer
Methyl 3-(trifluoromethyl)benzoate is typically synthesized by the methylation of 3-(trifluoromethyl)benzoic acid using methyl iodide in the presence of a base like sodium hydride. The reaction is carried out in a solvent such as dimethylformamide (DMF) at room temperature, with a yield of around 80-85%. The reaction involves the formation of a triflate intermediate which then reacts with methyl iodide to form the desired product.
About
CAS No
2557-13-3
English Name
Methyl 3-(trifluoromethyl)benzoate
Molecular Formula
C9H7F3O2
Molecular Weight
204.15 g/mol
SMILES
COC(=O)C1=CC(=CC=C1)C(F)(F)F
InChIKey
QQHNNQCWKYFNAC-UHFFFAOYSA-N
Last Updated: 2025-09-08 00:42
