Compound Q&A
How is Pemetrexed (CAS: 137281-23-3) typically synthesized?
Answer
Pemetrexed is typically synthesized via a multi-step process involving nucleophilic substitution reactions. The key step involves the coupling of a 5,4′-diaminopurine with a 4-aminolevulinic acid derivative. This process often requires the use of catalytic amounts of a tertiary amine and metal catalysts like palladium to achieve high selectivity and yield.
About
CAS No
137281-23-3
English Name
Pemetrexed
Molecular Formula
C20H21N5O6
Molecular Weight
427.42 g/mol
SMILES
Nc1nc2[nH]cc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)c2c(=O)[nH]1
InChIKey
WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
Last Updated: 2025-09-08 00:42
