Methyl (2S)-2,3-dihydroxypropanoate|pharmaceutical intermediates(CAS: 10303-88-5)

Methyl (2S)-2,3-dihydroxypropanoate is a colorless liquid with a molecular weight of approximately 122.09 g/mol. It has a strong solubility in water and poor solubility in organic solvents. The compound is moderately reactive, showing potential for esterification and condensation reactions. Its physical properties include a boiling point of 180-181°C and a melting point of -21°C to -20°C.

Methyl (2S)-2,3-dihydroxypropanoate is typically synthesized via the hydration of methyl 2-bromopropanoate using sodium hydroxide in water. This method provides good yield and selectivity, with the addition of a catalyst such as potassium tert-butoxide to improve the reaction efficiency. The reaction is carried out under mild conditions, ensuring a high purity product.

Methyl (2S)-2,3-dihydroxypropanoate finds applications in various industries. It is used in the pharmaceutical sector for the production of certain drugs, in the polymer industry as a monomer, in sensor technology for detecting specific substances, and in semiconductor manufacturing for etching processes. Its versatility makes it a valuable chemical in these and other sectors.

When handling Methyl (2S)-2,3-dihydroxypropanoate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using absorbent materials, and the area should be flushed with water. Ensure that the Safety Data Sheet (SDS) is readily available for reference during handling and storage.