5-Chloro-1,2,4-thiadiazole|pharmaceutical intermediates(CAS: 38362-15-1)

5-Chloro-1,2,4-thiadiazole (CAS: 38362-15-1) is a crystalline solid with a molecular weight of approximately 157.01 g/mol. It has a solubility of 1.6 g/L in water and is slightly soluble in ethanol and acetone. It exhibits good thermal stability and is reactive towards nucleophiles, particularly amines and thiols, forming adducts and reducing its chloro group.

5-Chloro-1,2,4-thiadiazole (CAS: 38362-15-1) is commonly synthesized via the reaction of thiophosgene with chloroform in the presence of a base such as potassium carbonate. The reaction yields high purity product with high selectivity and good yield, making it a viable method for industrial production.

5-Chloro-1,2,4-thiadiazole (CAS: 38362-15-1) is used in various industries, including pharmaceuticals for its antifungal and antibacterial properties, in the synthesis of polymers for its stability and solubility, in chemical sensors for its reactivity with various analytes, and in semiconductor production for its use as a precursor in the manufacturing of electronic materials.

When handling 5-Chloro-1,2,4-thiadiazole (CAS: 38362-15-1), it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be performed in a well-ventilated area or fume hood. Spills should be handled carefully, using appropriate cleaning materials to avoid skin contact or inhalation. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.