(5-PHENYLISOXAZOL-3-YL)METHYLAMINE(CAS: 154016-47-4)

1-(5-Phenyl-1,2-oxazol-3-yl)methanamine is a crystalline solid at room temperature. Its molecular weight is approximately 210.23 g/mol. It is slightly soluble in water but highly soluble in organic solvents like ethanol and acetone. This compound exhibits moderate reactivity, particularly towards nucleophiles and bases. It is stable under normal storage conditions but should be protected from strong acids and oxidizing agents.

1-(5-Phenyl-1,2-oxazol-3-yl)methanamine can be synthesized through the reaction of 5-phenyl-3-(methoxymethyl)oxazole with ammonia or an amine under basic conditions. The key steps involve the formation of the oxazolone ring followed by deprotection to form the amine. This process usually involves mild base catalysis and yields up to 85% purity.

1-(5-Phenyl-1,2-oxazol-3-yl)methanamine is primarily used in the pharmaceutical industry for the development of novel drugs. It is also utilized in polymer chemistry for modifying materials and in sensor technology for detecting specific chemical species. Its applications in semiconductors are limited but it can be used as a dopant in certain semiconductor devices.

When handling 1-(5-Phenyl-1,2-oxazol-3-yl)methanamine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Material Safety Data Sheet (MSDS/SDS) for specific safety guidelines and disposal procedures.