2-FLUORO-5-METHYLPHENYLBORONIC ACID(CAS: 166328-16-1)

(2-Fluoro-5-methylphenyl)boronic acid is a white or off-white crystalline powder with a molecular weight of approximately 216.13 g/mol. It is slightly soluble in water and has good solubility in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong oxidizing agents. It is often used in organic synthesis and biotechnology applications due to its reactivity and stability.

(2-Fluoro-5-methylphenyl)boronic acid is commonly synthesized through the coupling of 2-fluoro-5-methylphenol with boron tribromide in the presence of a base like sodium hydroxide. This method provides good yields and selectivity. Other synthetic routes include the use of boronic esters with fluoride sources in the presence of phase transfer catalysts.

(2-Fluoro-5-methylphenyl)boronic acid is widely used in the pharmaceutical industry for drug synthesis, particularly in the development of anti-inflammatory and anti-cancer drugs. It also finds applications in the polymer industry for the synthesis of functional polymers, in biotechnology for DNA probes, and in the electronics industry for the production of semiconductors and sensors.

When handling (2-Fluoro-5-methylphenyl)boronic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up immediately with appropriate absorbent materials. Refer to the Safety Data Sheet (SDS) for detailed emergency procedures and disposal methods. Avoid contact with eyes and skin, and do not ingest or inhale the compound.