Compound Q&A
How is (2-Fluoro-5-methylphenyl)boronic acid (CAS: 166328-16-1) typically synthesized?
Answer
(2-Fluoro-5-methylphenyl)boronic acid is commonly synthesized through the coupling of 2-fluoro-5-methylphenol with boron tribromide in the presence of a base like sodium hydroxide. This method provides good yields and selectivity. Other synthetic routes include the use of boronic esters with fluoride sources in the presence of phase transfer catalysts.
About
CAS No
166328-16-1
English Name
(2-Fluoro-5-methylphenyl)boronic acid
Molecular Formula
C7H8BFO2
Molecular Weight
153.95 g/mol
SMILES
B(C1=C(C=CC(=C1)C)F)(O)O
InChIKey
ZLODKAZZRDLUKX-UHFFFAOYSA-N
Last Updated: 2025-10-16 16:48
