Ethyl [(4-fluorophenyl)amino](oxo)acetate(CAS: 69065-91-4)

Ethyl [(4-fluorophenyl)amino](oxo)acetate is a white to off-white solid with a molecular weight of approximately 248.19 g/mol. It has a solubility of about 100 mg/L in water and is soluble in common organic solvents. This compound is moderately reactive, particularly towards nucleophiles and bases. It is stable under normal storage conditions but should be handled in a fume hood to avoid inhalation. It has limited reactivity with common laboratory reagents.

Ethyl [(4-fluorophenyl)amino](oxo)acetate is typically synthesized via a multi-step process involving the reaction of ethyl chloroacetate with 4-fluoroaniline followed by oxidation. This reaction is catalyzed by a suitable oxidizing agent such as sodium hypochlorite or potassium permanganate. The yield is generally around 70-80%, and the method provides high selectivity for the desired product.

Ethyl [(4-fluorophenyl)amino](oxo)acetate is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also of interest in polymer science where it can be used as a monomer. Additionally, it has applications in the production of sensors and other electronic components due to its chemical functionality.

When handling Ethyl [(4-fluorophenyl)amino](oxo)acetate, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area, such as a fume hood, to prevent inhalation. In case of a spill, use absorbent materials and dispose of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety guidelines.