5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine(CAS: 918516-27-5)

5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine is a crystalline solid with a molecular weight of approximately 241.17 g/mol. It is slightly soluble in water but more soluble in organic solvents such as ethanol and acetone. The compound is moderately reactive, particularly towards nucleophiles and bases, and it tends to undergo substitution reactions under certain conditions.

5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine is typically synthesized via the chlorination of 1-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-5(4H)-one. This process involves the use of a Lewis acid catalyst, such as aluminum chloride, in a suitable solvent like dichloromethane. The reaction is sensitive to temperature and requires careful control to achieve high yield and selectivity.

5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine is primarily used in the pharmaceutical industry as an intermediate for drug synthesis. It can also be used in the chemical industry for the development of new materials, particularly in the areas of polymers and sensors. Its potential in semiconductors is also being explored, although it is not yet widely used in this field.

When handling 5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine, it is essential to use proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from direct sunlight. In case of spillage, the area should be handled in a well-ventilated fume hood, and appropriate disposal methods should be followed. For detailed safety information, refer to the Material Safety Data Sheet (MSDS).