2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide(CAS: 761440-08-8)

2-[(2,5-Dichloropyrimidin-4-yl)amino]-N-methyl-benzamide (CAS: 761440-08-8) is a crystalline compound with a molecular weight of approximately 356.02 g/mol. It has a pKa of about 8.0, indicating it is a weak base. The compound is sparingly soluble in water but soluble in organic solvents such as methanol and dimethylformamide. It exhibits good stability under normal conditions but may react with strong acids or bases. This compound is also sensitive to light, so it should be stored in a dry, dark place.

2-[(2,5-Dichloropyrimidin-4-yl)amino]-N-methyl-benzamide (CAS: 761440-08-8) is typically synthesized via a multistep process involving the reaction of 2,5-dichloropyrimidine-4-amine with methylbenzoyl chloride in the presence of a suitable base such as triethylamine. The reaction yields the desired product with good selectivity and moderate to high yield, depending on the conditions.

2-[(2,5-Dichloropyrimidin-4-yl)amino]-N-methyl-benzamide (CAS: 761440-08-8) is primarily used in the pharmaceutical industry for its potential as an antiviral and antitumor agent. It also has applications in the production of sensors and in the development of materials for use in semiconductors and polymers.

When handling 2-[(2,5-Dichloropyrimidin-4-yl)amino]-N-methyl-benzamide (CAS: 761440-08-8), it is important to wear proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize exposure to vapors. In case of a spill, it should be immediately cleaned up using appropriate absorbent materials, and the area should be thoroughly flushed with water. Always refer to the safety data sheet (SDS) for specific handling instructions and emergency procedures.