3-Methyl-3H-spiro[2-benzofuran-1,4'-piperidine](CAS: 747353-15-7)

3-Methyl-3H-spiro[2-benzofuran-1,4'-piperidine] is a solid with a crystalline form. Its molecular weight is approximately 250.32 g/mol. This compound is poorly soluble in water but soluble in organic solvents like dichloromethane and ethanol. It is moderately reactive, particularly towards nucleophiles and electrophiles. It has a pKa of around 8.0, indicating basicity.

3-Methyl-3H-spiro[2-benzofuran-1,4'-piperidine] is typically synthesized via the reaction of benzofuran and piperidine under basic conditions using sodium hydride as a catalyst. The yield is generally around 70-80%, and the reaction involves the formation of a spiro cyclohexane intermediate. The product is purified by recrystallization from a suitable solvent.

3-Methyl-3H-spiro[2-benzofuran-1,4'-piperidine] is primarily used in the pharmaceutical industry for the development of new drugs. It also finds applications in the polymer industry, particularly in the synthesis of biodegradable polymers. Additionally, it can be used in sensors for detecting organic compounds and in semiconductor materials for specific electronic applications.

When handling 3-Methyl-3H-spiro[2-benzofuran-1,4'-piperidine], it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated area or a fume hood to avoid exposure. In case of a spill, neutralize the compound with a suitable agent and clean up using appropriate procedures. Always consult the safety data sheet (SDS) for detailed information on handling and disposal.