Amylin (8-37) (human)(CAS: 135702-23-7)

Amylin (8-37) (human) (CAS: 135702-23-7) is a polypeptide with a molecular weight of approximately 1,500 Daltons. It is a crystalline solid with good solubility in water and limited solubility in organic solvents. Chemically, it is highly reactive, particularly towards strong acids and bases, and is susceptible to proteolytic degradation under non-sterile conditions. It is stable under neutral pH conditions and at temperatures below 30°C.

Amylin (8-37) (human) (CAS: 135702-23-7) is synthesized through solid-phase peptide synthesis (SPPS). The process involves sequential coupling of amino acids, using Fmoc chemistry and HBTU coupling reagent. The peptide is then cleaved from the resin using trifluoroacetic acid (TFA) and subsequent purification is achieved through HPLC. The synthesis typically yields a purity of over 95%, with excellent regioselectivity and good yield.

Amylin (8-37) (human) (CAS: 135702-23-7) is primarily used in the pharmaceutical industry for research and development of diabetes treatments. It is also utilized in the biotechnology sector for peptide-based drug discovery and in academic and industrial laboratories for its structural and functional studies. Its applications in polymers and sensors are limited due to its biological nature.

When handling Amylin (8-37) (human) (CAS: 135702-23-7), it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be stored in a cool, dry place away from direct sunlight and moisture. Spills should be handled with care using appropriate absorbent materials, and the area should be flushed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.