1H-Pyrrolo[2,3-b]pyridin-3-amine(CAS: 189882-31-3)

1H-Pyrrolo[2,3-b]pyridin-3-amine is a solid with a crystalline form. Its molecular weight is approximately 163.19 g/mol. It has a low solubility in water but is soluble in common organic solvents such as methanol and dimethylformamide. This compound is moderately reactive, particularly towards nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

1H-Pyrrolo[2,3-b]pyridin-3-amine can be synthesized via the reaction of 3-formylpyrrolo[2,3-b]pyridine with ammonia under basic conditions. The reaction typically involves refluxing the mixture in an aqueous ammonia solution. The yield is around 75-80%, and the product is isolated by recrystallization from a suitable solvent.

1H-Pyrrolo[2,3-b]pyridin-3-amine finds applications in various industries. It is used in the pharmaceutical industry as an intermediate for drug synthesis. In materials science, it is employed in the development of conductive polymers and organic semiconductors. Additionally, it is utilized in the fabrication of chemical sensors due to its unique electronic properties.

When handling 1H-Pyrrolo[2,3-b]pyridin-3-amine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats. This material should be handled in a well-ventilated area or a laboratory fume hood to minimize inhalation risk. In case of spillage, ensure proper disposal according to safety data sheet (SDS) guidelines. Always refer to the SDS for detailed safety information and emergency procedures.