Ambroxol HCl | CAS No. 23828-92-4

Ambroxol HCl

Basic Information

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CAS Number

23828-92-4

Molecular Formula

C13H19Br2ClN2O

Molecular Weight

414.57 g/mol

Basic Physical Properties

Physical State

Powder

Melting Point

235°C(dec.)

Boiling Point

492.6°C at 760 mmHg

Water Solubility

Slightly soluble in water (~5 mg/ml) or ethanol (~5 mg/ml).

Flash Point

237.2ºC

SMILES

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O[C@@H]1CC[C@H](CC1)NCc1cc(Br)cc(c1N)Br.Cl

InChI

InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;

InChIKey

QNVKOSLOVOTXKF-PFWPSKEQSA-N

LogP

3.608700000000002

Topological Polar Surface Area

58.28 Å²

Hydrogen Bond Donor/Acceptor

4 / 3

Complexity

259

Safety Information

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GHS Hazard Pictograms

H303

Hazard Statement

H303 May be harmful if swallowed
Acute toxicity, oral

Toxicity

LD50 in mice, rats (mg/kg): 268, 380 i.p.; 2720, 13400 orally (Püschmann, Engelhorn)

Synonyms & References

English

Ambroxol hydrochloride
DURAMUCAL
FLUIXOL
FRENOPECT
BLUIBRON
BRONCHOPRONT
ABRAMEN
AMBROXOL HCL
ambroxol
cis-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride
2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine
AMBRIL
Ambron
Ankisol
Antobron
mucolear
Stas-Hustenloser
trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride
Ambroxol Impurity 9
trans-4-[[(2-Amino-3,5-dibromo-phenyl)methyl]amino]-cyclohexanol hydrochloride
AMbroxoliMpurity
Mucosolvan
Mucoangin
Ambroxolhydrochloride
Ambroxol hydrochloride
trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride
Ambroxol Hydrochloride [JAN]
CC995ZMV90
Ambroxol hydrochloride (JAN)
2-Amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzylamine
4-((2-amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol hydrochloride

MDL Number

MFCD00078932

Customs Code

2922199090

FAQ

What is Ambroxol HCl (CAS: 23828-92-4)?

Ambroxol HCl is a mucolytic agent used to treat respiratory conditions by thinning mucus and making it easier to expel. Its chemical formula is C14H27BrO3Cl, and it is a white to off-white crystalline powder with good solubility in water. It is commonly used in pharmaceutical formulations for its expectorant properties.

What are the main uses of Ambroxol HCl (CAS: 23828-92-4)?

Ambroxol HCl is primarily used in the treatment of coughs and respiratory tract diseases such as bronchitis and asthma. It helps to break down mucus, improve airflow, and reduce congestion. It is also used in the formulation of various over-the-counter and prescription medications for respiratory support.

Is Ambroxol HCl (CAS: 23828-92-4) safe?

Ambroxol HCl is generally considered safe when used as directed. It has low toxicity and is well-tolerated by most patients. However, it should be handled with care, and protective measures such as gloves and proper ventilation are recommended during preparation and use. Safety standards ensure its quality and purity for medical use.

How should Ambroxol HCl (CAS: 23828-92-4) be stored?

Ambroxol HCl should be stored in a cool, dry place away from direct sunlight. It is stable at room temperature (15–25°C) and should be kept in a tightly sealed container to prevent moisture exposure. Proper storage ensures its efficacy and maintains the chemical integrity of the compound.