(1S)-1-(2-methoxyphenyl)propan-1-amine;hydrochloride(CAS: 873893-95-9)

The compound (1S)-1-(2-methoxyphenyl)propan-1-amine hydrochloride is a white crystalline solid with a molecular weight of approximately 258.3 g/mol. It has a pKa of about 8.8. The compound is slightly soluble in water but more soluble in organic solvents like ethanol. It is known for its low reactivity with common reagents, but it can undergo hydrolysis under acidic conditions. It is stable under normal storage conditions, but it is advisable to store it in a sealed container to protect it from moisture and light.

Synthesis of (1S)-1-(2-methoxyphenyl)propan-1-amine hydrochloride typically involves the reaction of 2-methoxyphenylglycine with hydrochloric acid. The reaction is usually conducted in a polar aprotic solvent such as dimethylformamide (DMF) under reflux conditions. The yield is around 80-85%, and the product is isolated by recrystallization from a suitable solvent. The reaction is selective and provides good purity.

The compound (1S)-1-(2-methoxyphenyl)propan-1-amine hydrochloride finds application primarily in the pharmaceutical industry. It is used as an intermediate in the synthesis of various drugs. Additionally, it can be used in the polymer industry as a surfactant, and in the sensor and semiconductor industries as a functional material due to its amine functionality and hydrochloride salt form.

When handling (1S)-1-(2-methoxyphenyl)propan-1-amine hydrochloride, appropriate personal protective equipment (PPE) should be worn, including gloves, safety goggles, and a lab coat. It should be handled in a well-ventilated area or under a fume hood to avoid inhalation. Spills should be cleaned up immediately using appropriate absorbent materials. It is important to refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal. The compound is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight and heat sources.