1-Chloro-4-(2-chloroethoxy)benzene(CAS: 13001-28-0)

1-Chloro-4-(2-chloroethoxy)benzene is a colorless to pale yellow liquid with a molecular weight of approximately 242.05 g/mol. It has a low solubility in water and is more soluble in organic solvents. This compound is relatively stable under normal conditions but is reactive towards nucleophiles due to the presence of chlorine substituents. It has a density of around 1.098 g/cm³ and a boiling point of about 168°C.

1-Chloro-4-(2-chloroethoxy)benzene can be synthesized through the reaction of 4-chloroaniline with 2-chloroethanol in the presence of a base such as potassium carbonate. The reaction involves nucleophilic substitution, yielding a high yield of the target compound. The process is performed under anhydrous conditions to prevent side reactions. The product is purified by recrystallization or distillation.

1-Chloro-4-(2-chloroethoxy)benzene is primarily used in the pharmaceutical industry for the synthesis of certain active pharmaceutical ingredients. It also finds applications in the polymer industry as a monomer or intermediate. Additionally, it is utilized in the production of chemical sensors and as a precursor in semiconductor manufacturing processes.

When handling 1-Chloro-4-(2-chloroethoxy)benzene, safety goggles, gloves, and appropriate personal protective equipment (PPE) should be worn to prevent skin and eye contact. Work should be carried out in a well-ventilated area or a fume hood to minimize inhalation of vapors. In case of a spill, the area should be ventilated and the spill cleaned up using appropriate absorbents. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.