(2-Chloro-3-quinolinyl)boronic acid(CAS: 128676-84-6)

(2-Chloro-3-quinolinyl)boronic acid is a crystalline solid with a molecular weight of approximately 245.01 g/mol. It has a low solubility in water but is soluble in organic solvents like dichloromethane and ethanol. The compound is known for its reactivity towards boronic acid coupling reactions, commonly used in organic synthesis.

(2-Chloro-3-quinolinyl)boronic acid is typically synthesized by the reaction of 3-quinolylboronic acid with chlorine gas in the presence of a catalyst, such as iron(III) chloride. The reaction is selective and yields a high percentage of the desired product, making it a common method in the synthesis of boronic acids.

(2-Chloro-3-quinolinyl)boronic acid finds applications in the pharmaceutical industry for the synthesis of drug intermediates, in the polymer industry for the modification of materials, and in the sensor industry for the development of chemical sensors. It is also used in semiconductor manufacturing for certain processing steps.

When handling (2-Chloro-3-quinolinyl)boronic acid, it is important to wear protective gloves, goggles, and a lab coat. Ensure that all operations are conducted in a fume hood to minimize exposure to vapors. In case of a spill, immediately clean up with caution, using appropriate personal protective equipment and following standard safety procedures. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency response instructions.