(1S)-1-(3-Nitrophenyl)ethanamine(CAS: 297730-25-7)

(1S)-1-(3-Nitrophenyl)ethanamine is a crystalline solid with a molecular weight of approximately 185.11 g/mol. It has a pKa of around 8.5 and is poorly soluble in water but more soluble in organic solvents like ethanol and acetone. The compound is moderately reactive, especially under basic conditions, and can undergo substitution reactions. It sublimes readily and has a distinct odor.

(1S)-1-(3-Nitrophenyl)ethanamine can be synthesized by the reaction of 3-nitrophenol with ethylamine in the presence of a base like sodium hydroxide. The reaction proceeds via an alkyl substitution mechanism, yielding a high yield of the desired product. The process is typically conducted under mild conditions to ensure selectivity and yield.

(1S)-1-(3-Nitrophenyl)ethanamine finds applications in various industries, particularly in the pharmaceutical sector where it serves as a precursor for the synthesis of certain azo dyes and as a building block for drug development. It is also used in the production of organic semiconductors and in the development of chemical sensors.

When handling (1S)-1-(3-Nitrophenyl)ethanamine, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up immediately using appropriate absorbent materials. Always consult the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and follow all laboratory safety guidelines.