3-Chloro-5-methoxyisonicotinic acid(CAS: 214976-36-0)

3-Chloro-5-methoxyisonicotinic acid (CAS: 214976-36-0) is a crystalline solid with a molecular weight of approximately 224.59 g/mol. It has a melting point of about 200-202°C and a solubility of about 35 mg/L in water. This compound is moderately reactive, particularly towards nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight and moisture.

3-Chloro-5-methoxyisonicotinic acid (CAS: 214976-36-0) is commonly synthesized via the condensation of 3-chloroisonicotinic acid with methanol in the presence of an acid catalyst such as sulfuric acid. The reaction typically yields a mixture that requires purification steps including recrystallization to obtain the pure compound. The process is selective and often gives good yields, around 70-80%.

3-Chloro-5-methoxyisonicotinic acid (CAS: 214976-36-0) finds application in the pharmaceutical industry for the synthesis of certain drugs due to its biological activity. It is also used in the production of organic semiconductors and sensors. Due to its chemical properties, it is sometimes employed in polymer chemistry for modifying polymers' properties. Its specific uses vary depending on the industry and the desired end product.

When handling 3-Chloro-5-methoxyisonicotinic acid (CAS: 214976-36-0), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood due to its potential volatility. In case of a spill, ensure proper disposal according to local regulations and consult the Safety Data Sheet (SDS) for specific instructions. Always store the compound in a cool, dry place away from incompatible materials.