N,N'-(2-Chloro-5-methyl-1,4-phenylene)bis(3-oxobutanamide)(CAS: 41131-65-1)

N,N'-(2-Chloro-5-methyl-1,4-phenylene)bis(3-oxobutanamide) is a crystalline solid with a molecular weight of approximately 318.8 g/mol. It has limited water solubility but is soluble in organic solvents like methanol and acetonitrile. The compound exhibits moderate reactivity, particularly towards nucleophiles and bases. It is stable under normal storage conditions but should be protected from moisture and strong acids.

N,N'-(2-Chloro-5-methyl-1,4-phenylene)bis(3-oxobutanamide) can be synthesized via a multistep process involving chlorination of a phenol, followed by reaction with an amine and subsequent acylation. The reaction typically uses a strong base like sodium hydride and a coupling reagent such as EDC/HOBt. The yield is moderate, and the product is isolated by recrystallization. The exact conditions may vary based on desired purity and scale of synthesis.

N,N'-(2-Chloro-5-methyl-1,4-phenylene)bis(3-oxobutanamide) finds application in the pharmaceutical industry for the synthesis of certain compounds. It is also used in the preparation of materials for sensors and some types of polymers. Its specific role in these industries often involves its use as an intermediate or building block due to its functional groups and stability.

When handling N,N'-(2-Chloro-5-methyl-1,4-phenylene)bis(3-oxobutanamide), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the area is well-ventilated to avoid inhalation of vapors. Store the compound in a cool, dry place away from moisture and strong acids. In case of spill, follow standard protocols for handling crystalline solids, and consult the Safety Data Sheet (SDS) for specific guidance.