(R)-3,3'-Bis[4-(trifluoromethyl)phenyl]-[1,1'-binaphthalene]-2,2'-diol(CAS: 791616-58-5)

(R)-3,3'-Bis[4-(trifluoromethyl)phenyl]-[1,1'-binaphthalene]-2,2'-diol is a crystalline compound with a molecular weight of approximately 565.39 g/mol. It has low solubility in water but is soluble in organic solvents like dichloromethane and acetonitrile. The compound shows moderate reactivity towards electrophilic aromatic substitution and can form stable adducts with various transition metal complexes.

(R)-3,3'-Bis[4-(trifluoromethyl)phenyl]-[1,1'-binaphthalene]-2,2'-diol can be synthesized via a multistep process involving the coupling of 4-(trifluoromethyl)benzaldehyde with 1,1'-binaphthol in the presence of a Lewis acid catalyst. The reaction involves the formation of a key intermediate, which is then coupled to yield the final product. The overall yield is generally moderate, with careful control of reaction conditions ensuring high selectivity.

(R)-3,3'-Bis[4-(trifluoromethyl)phenyl]-[1,1'-binaphthalene]-2,2'-diol finds applications in the pharmaceutical industry for its potential as a scaffold in drug discovery. It is also used in the polymer industry for developing novel materials with specific electronic properties. Additionally, it has applications in the semiconductor industry due to its unique electronic properties and in chemical sensors for its selective reactivity.

When handling (R)-3,3'-Bis[4-(trifluoromethyl)phenyl]-[1,1'-binaphthalene]-2,2'-diol, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coat. This compound should be used in a well-ventilated area or a fume hood due to its potential volatility. In case of a spill, it should be cleaned up immediately with appropriate absorbent materials and disposed of according to local regulations. For more detailed safety information, refer to the Material Safety Data Sheet (MSDS/SDS) for this compound.