1-Bromo-3-fluoro-5-(trifluoromethyl)benzene(CAS: 130723-13-6)

1-Bromo-3-fluoro-5-(trifluoromethyl)benzene is a crystalline solid with a molecular weight of approximately 287.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and acetonitrile. The compound is relatively inert under normal conditions but can react with bases and reducing agents. It is used in organic synthesis as a brominating agent and precursor in pharmaceuticals and polymers.

1-Bromo-3-fluoro-5-(trifluoromethyl)benzene can be synthesized via bromination of 3-fluoro-5-(trifluoromethyl)benzene using N-bromosuccinimide (NBS) in the presence of a radical initiator like benzoyl peroxide. The reaction involves the formation of a highly substituted benzene ring with a bromine, fluoro, and trifluoromethyl group, providing high selectivity and yield.

1-Bromo-3-fluoro-5-(trifluoromethyl)benzene is primarily used in the pharmaceutical and polymer industries. It serves as a precursor for the synthesis of various fluorinated compounds and is employed in the development of new materials with specific electronic and mechanical properties. Additionally, it is used in the manufacturing of sensors and semiconductors due to its unique chemical structure.

When handling 1-Bromo-3-fluoro-5-(trifluoromethyl)benzene, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and laboratory coats. The compound should be stored in a cool, dry place away from incompatible substances. In case of a spill, immediately clean up with appropriate absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.