Ethyl azidoacetate(CAS: 637-81-0)

Ethyl azidoacetate (CAS: 637-81-0) is a colorless to slightly yellow liquid with a molecular weight of approximately 110.11 g/mol. It has a pungent odor and is highly soluble in water and organic solvents. Chemically, it is reactive and can undergo nucleophilic substitution reactions. It is also unstable to light and heat, decomposing into acetic acid and azide ion.

Ethyl azidoacetate is typically synthesized by reacting acetyl chloride with sodium azide in an aprotic solvent like dimethylformamide (DMF). The reaction is catalyzed by a base such as potassium carbonate and occurs at room temperature. The yield is usually around 85-90%, and the product is purified by recrystallization or distillation.

Ethyl azidoacetate is used in various industries, including pharmaceuticals for drug synthesis, polymers for modifying polymers, sensors for detecting nitrite, and semiconductors for photolithography. It plays a crucial role in these fields due to its reactivity and ability to introduce azide groups into molecules.

Handling Ethyl azidoacetate (CAS: 637-81-0) requires strict safety protocols. It should be stored in a cool, dry place away from heat and light. Personal protective equipment (PPE) such as gloves, goggles, and a lab coat must be worn. Fume hoods should be used during handling to avoid inhalation. In case of spill, immediately neutralize with a base and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.