3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole(CAS: 1314138-13-0)

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole is a solid, crystalline compound with a molecular weight of approximately 372.46 g/mol. It is slightly soluble in common organic solvents like dimethylformamide (DMF) and acetone. The compound shows moderate reactivity towards nucleophiles and can undergo substitution reactions under appropriate conditions. Its physical properties include a melting point of around 165-167°C.

This compound can be synthesized by palladium-catalyzed coupling reactions of boronic acids with 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole derivatives. Commonly used catalysts include Pd(PPh3)4 or PdCl2(dppf). The reaction typically provides good yield and selectivity, with the products being isolated by column chromatography.

This compound is primarily used in pharmaceutical and material science industries. It serves as a key intermediate in the synthesis of complex organic molecules and is utilized in the development of new drug candidates. Additionally, it has applications in the synthesis of functional polymers and as a building block in the construction of advanced materials.

When handling this compound, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed information on handling and storage procedures.