4-Chloro-5-nitro-2-pyridinamine(CAS: 24484-96-6)

4-Chloro-5-nitro-2-pyridinamine is a crystalline solid with a molecular weight of approximately 210.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and acetone. This compound is known for its reactivity due to the presence of the nitro and chlorine groups, which can participate in various chemical reactions such as nucleophilic substitution and electrophilic aromatic substitution.

4-Chloro-5-nitro-2-pyridinamine can be synthesized by the nitration of 4-chloro-2-pyridinamine followed by acetylation and hydrolysis. Alternatively, it can be obtained through the chlorination of 5-nitro-2-pyridinamine. The nitration process requires careful control of temperature and concentration to achieve the desired product with good selectivity and yield.

4-Chloro-5-nitro-2-pyridinamine is used in various industries, particularly in the pharmaceutical sector for the synthesis of drug intermediates. It also finds application in the production of organic dyes and in the development of sensors and semiconductors due to its unique chemical properties.

When handling 4-Chloro-5-nitro-2-pyridinamine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of fumes. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Always consult a safety data sheet (SDS) for detailed handling and emergency procedures.