2,4-Dichloro-5-pyrimidinol(CAS: 1395037-19-0)

2,4-Dichloro-5-pyrimidinol is a white crystalline powder with a high melting point of 250-252°C. Its molecular weight is approximately 181.03 g/mol. This compound is poorly soluble in water but soluble in common organic solvents such as ethanol and acetone. It exhibits moderate reactivity, particularly towards nucleophiles and reducing agents.

2,4-Dichloro-5-pyrimidinol can be synthesized via the reaction of 5-amino-2,4-dichloropyrimidine with sodium hydroxide. The reaction is typically carried out in an aqueous medium, yielding a high purity product with selectivity and a yield of up to 85%. The process is optimized using appropriate temperature and catalysts to enhance efficiency.

2,4-Dichloro-5-pyrimidinol is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also has applications in the polymer industry for the production of biodegradable polymers. Additionally, it is used in the development of sensors and semiconductors due to its unique chemical properties.

When handling 2,4-Dichloro-5-pyrimidinol, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate methods as outlined in the Safety Data Sheet (SDS). Ensure to follow all laboratory safety guidelines and handle this compound with care due to its chemical nature.