N-Methyl-4-({4-[({3-[methyl(methylsulfonyl)amino]-2-pyrazinyl}methyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl}amino)benzamide(CAS: 1073154-85-4)

N-Methyl-4-({4-[({3-[methyl(methylsulfonyl)amino]-2-pyrazinyl}methyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl}amino)benzamide is a white or off-white crystalline solid with a molecular weight of approximately 622.75 g/mol. It is poorly soluble in water but soluble in organic solvents such as DMSO and DMF. This compound is known for its high reactivity towards nucleophiles and its ability to undergo conjugate addition reactions. It is also stable under acidic and basic conditions.

N-Methyl-4-({4-[({3-[methyl(methylsulfonyl)amino]-2-pyrazinyl}methyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl}amino)benzamide is synthesized through multistep reactions involving the formation of pyrazinyl and pyrimidinyl intermediates. The synthesis typically requires the use of catalytic amounts of a Lewis acid, such as zinc chloride, and involves selective amination reactions. The yield is generally high, around 75-80%, and the product is isolated by recrystallization from organic solvents.

N-Methyl-4-({4-[({3-[methyl(methylsulfonyl)amino]-2-pyrazinyl}methyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl}amino)benzamide is primarily used in the pharmaceutical industry due to its potential as a bioactive compound. It may also have applications in the development of sensors and as a building block in pharmaceutical and polymer synthesis.

When handling N-Methyl-4-({4-[({3-[methyl(methylsulfonyl)amino]-2-pyrazinyl}methyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl}amino)benzamide, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up using appropriate procedures as outlined in the Material Safety Data Sheet (MSDS/SDS). Storage should be in a cool, dry place away from direct sunlight and ignition sources.