How is N-Methyl-4-({4-[({3-[methyl(methylsulfonyl)amino]-2-pyrazinyl}methyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl}amino)benzamide (CAS: 1073154-85-4) typically synthesized?

N-Methyl-4-({4-[({3-[methyl(methylsulfonyl)amino]-2-pyrazinyl}methyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl}amino)benzamide is synthesized through multistep reactions involving the formation of pyrazinyl and pyrimidinyl intermediates. The synthesis typically requires the use of catalytic amounts of a Lewis acid, such as zinc chloride, and involves selective amination reactions. The yield is generally high, around 75-80%, and the product is isolated by recrystallization from organic solvents.