Prochlorperazine-d8(CAS: 1215641-01-2)

Prochlorperazine-d8 (CAS: 1215641-01-2) is a derivative of prochlorperazine, a phenothiazine antipsychotic. It has a white to off-white crystalline form with a molecular weight of approximately 432.48 g/mol. It is poorly soluble in water but soluble in ethanol. Chemically, it is reactive towards bases and oxidizing agents, making it susceptible to degradation under basic conditions.

Prochlorperazine-d8 is synthesized by the alkylation of prochlorperazine with 1,4-dioxa-8-azasnorcamphor-8-carboxylic acid, followed by derivatization with deuterium. The reaction typically proceeds under mild conditions using a suitable base, and the product is purified by recrystallization or column chromatography. The synthesis involves high selectivity and yields above 70%.

Prochlorperazine-d8 (CAS: 1215641-01-2) is primarily used in the pharmaceutical industry for research purposes. It is also used in analytical chemistry for isotopic labeling and as a reference compound in drug metabolism studies. Its applications extend to the polymer and sensor industries, where it can serve as a precursor or a component in specialized formulations.

When handling Prochlorperazine-d8 (CAS: 1215641-01-2), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation exposure. Spills should be cleaned up using appropriate absorbent materials and disposing of waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.