3-Hydroxyandrost-1-en-17-one(CAS: 76822-24-7)

3-Hydroxyandrost-1-en-17-one is a steroid compound. It is a white or off-white crystalline solid with a molecular weight of approximately 324.47 g/mol. The compound is slightly soluble in water and ethanol but more soluble in organic solvents like methanol and acetone. It is known for its reactivity towards nucleophiles and can undergo hydrolysis under basic conditions. It is also prone to oxidation)

3-Hydroxyandrost-1-en-17-one can be synthesized via a multi-step process starting from androst-1,4-dien-3-one. The synthesis involves reduction of the ketone, followed by hydroxylation, and finally, a series of alkylation reactions. Common catalysts include palladium on carbon and hydrogen for reduction steps. The overall yield is moderate, around 50-70%, depending on the purification and reaction conditions.

3-Hydroxyandrost-1-en-17-one is primarily used in the pharmaceutical industry for the synthesis of steroid hormones and progestins. It is also utilized in the production of certain agrochemicals and in research for its hormonal properties. Additionally, it has applications in the cosmetic industry for the development of skin care products with hormonal effects.

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 3-Hydroxyandrost-1-en-17-one. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up with care, using absorbent materials followed by neutralization with a suitable base. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.