tert-Butyl 4-bromoindoline-1-carboxylate(CAS: 885272-46-8)

tert-Butyl 4-bromoindoline-1-carboxylate (CAS: 885272-46-8) is a crystalline solid with a molecular weight of approximately 313.07 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and ethanol. The compound reacts readily with nucleophiles at the bromine substituent. It is stable under normal conditions but can decompose at elevated temperatures.

tert-Butyl 4-bromoindoline-1-carboxylate (CAS: 885272-46-8) is synthesized via a bromination reaction of tert-butyl indoline-1-carboxylate with N-bromosuccinimide (NBS) in the presence of AIBN (2,2'-azobisisobutyronitrile) as a radical initiator. The reaction is typically carried out under nitrogen atmosphere to avoid decomposition. The yield is generally around 70-80%.

tert-Butyl 4-bromoindoline-1-carboxylate (CAS: 885272-46-8) is used in the pharmaceutical industry for the synthesis of intermediates and in polymer science for improving the properties of polymers. It also has applications in the development of sensors and semiconductors due to its unique chemical structure. Its versatility makes it suitable for a range of advanced materials and technologies.

When handling tert-Butyl 4-bromoindoline-1-carboxylate (CAS: 885272-46-8), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety glasses, due to its reactivity. Work should be conducted in a well-ventilated area or fume hood to avoid inhaling the fumes. Spills should be cleaned up immediately using appropriate spill response materials. Always refer to the Safety Data Sheet (SDS) for specific handling and storage guidelines.