1-Methyl-4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperazine(CAS: 914610-39-2)

1-Methyl-4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperazine is a colorless solid with a molecular weight of approximately 582.6 g/mol. It has a solubility of 2.5 g/L in water and exhibits good solubility in organic solvents. This compound is known for its high reactivity, particularly towards nucleophiles. It is commonly used in medicinal chemistry and organic synthesis due to its versatile reactivity and structural complexity.

1-Methyl-4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperazine is typically synthesized via the coupling of 4-bromobenzene sulfonyl chloride with 1-methylpiperazine in the presence of a borate ester and a catalytic amount of a palladium complex, such as Pd(PPh3)4. The reaction is carried out under mild conditions, leading to high yields and good selectivity.

1-Methyl-4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperazine is primarily used in pharmaceuticals and medicinal chemistry due to its structural complexity and reactivity. It is also relevant in the synthesis of materials for polymers and sensors. This compound can be used as a key intermediate in the development of new drugs and in the creation of advanced materials.

When handling 1-Methyl-4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]piperazine (CAS: 914610-39-2), it is crucial to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, immediately clean up with appropriate absorbent materials and follow standard laboratory safety procedures. Always consult the Safety Data Sheet (SDS) for detailed information on handling and storage.