Diethyl (ethoxymethyl)phosphonate(CAS: 10419-80-4)

Diethyl (ethoxymethyl)phosphonate (CAS: 10419-80-4) is a colorless liquid with a molecular weight of approximately 168.22 g/mol. It has a specific gravity of 1.079 g/cm³ and a boiling point of 137-138°C. It is poorly soluble in water but readily soluble in ethanol and acetone. It is moderately reactive, particularly in the presence of acids or bases, and can undergo hydrolysis to form phosphoric acid derivatives.

Diethyl (ethoxymethyl)phosphonate (CAS: 10419-80-4) is typically synthesized through the phosphonylation of ethoxymethyl ether using phosphorus oxychloride or phosphorus pentoxide in the presence of a suitable solvent. The reaction is performed under anhydrous conditions to improve yield and selectivity. Common solvents include chloroform or dichloromethane.

Diethyl (ethoxymethyl)phosphonate (CAS: 10419-80-4) is used in various industries, including pharmaceuticals for certain intermediates and active pharmaceutical ingredients, and in the synthesis of organophosphorus compounds. It is also utilized in the development of sensors and as a reagent in analytical chemistry for specific applications.

When handling Diethyl (ethoxymethyl)phosphonate (CAS: 10419-80-4), it is important to use appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately with appropriate materials; avoid inhalation of the vapor and do not allow the material to come into contact with water. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.