5-Methyl-1,2,4-oxadiazole-3-carboxylic acid(CAS: 19703-92-5)

5-Methyl-1,2,4-oxadiazole-3-carboxylic acid is a colorless to white crystalline solid with a molecular weight of approximately 154.14 g/mol. It is slightly soluble in water and ethanol. Chemically, it is reactive towards nucleophiles and can participate in condensation reactions. It is also known for its ability to form stable complexes with metal ions.

5-Methyl-1,2,4-oxadiazole-3-carboxylic acid can be synthesized via various methods, including the condensation of 5-methylisoxazole-3-carboxylic acid with hydrogen cyanide followed by hydrolysis. This process yields the target compound with high selectivity and good yield. Other routes involve the reaction of methyl isoxazole-3-carboxylate with methyl isothiocyanate, followed by hydrolysis and oxidation.

5-Methyl-1,2,4-oxadiazole-3-carboxylic acid finds applications in the pharmaceutical industry as a precursor for drug synthesis, particularly in the development of anti-inflammatory and anti-cancer drugs. It is also utilized in the polymer industry for the preparation of functional polymers and in the chemical sensor industry for the fabrication of gas sensors.

When handling 5-Methyl-1,2,4-oxadiazole-3-carboxylic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and lab coat. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation of dust. In the event of a spill, it should be carefully cleaned up using appropriate absorbents. Always refer to the safety data sheet (SDS) for detailed safety guidelines.