2-Methoxy-6-methylnicotinonitrile(CAS: 72918-03-7)

2-Methoxy-6-methylnicotinonitrile is a crystalline solid with a molecular weight of approximately 188.21 g/mol. It has a high melting point of around 133-135°C and is soluble in organic solvents such as methanol and ethanol. This compound is moderately reactive, particularly towards nucleophiles, and can engage in substitution and addition reactions.

2-Methoxy-6-methylnicotinonitrile is commonly synthesized via a multistep process, starting from nicotinonitrile. The key steps involve methylation using methyl triflate as a methylating agent and subsequent methoxylation with methanol in the presence of a base like sodium methoxide. The overall yield is around 85-90% with good selectivity.

2-Methoxy-6-methylnicotinonitrile finds applications in various industries. It is primarily used in the pharmaceutical sector for synthesizing intermediates in drug formulations. Additionally, it plays a role in the polymer industry for the development of novel materials, and in the sensor industry for creating gas sensing devices.

When handling 2-Methoxy-6-methylnicotinonitrile, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. It should be stored in a closed container, away from direct sunlight and heat sources. In case of a spill, it should be dealt with using appropriate absorbent materials and the incident should be reported to the safety officer. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.