2-Chloro-4-fluoro-5-nitrophenol(CAS: 84478-75-1)

2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1) is a crystalline solid with a molecular weight of approximately 217.58 g/mol. It is slightly soluble in water and has a high solubility in organic solvents such as ethanol and acetone. This compound is reactive towards nucleophiles and reducing agents, making it suitable for various synthetic transformations. It is known for its strong absorption in the ultraviolet region, which makes it useful in spectroscopic applications.

2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1) can be synthesized through a multistep process involving the nitration of 4-fluoro-5-chlorophenol, followed by chlorination of the nitro derivative. This reaction typically requires strong acids such as sulfuric acid and high temperatures. The process is highly selective and yields up to 90% purity, depending on the reaction conditions and purification methods.

2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1) is primarily used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients. It also finds applications in the polymer industry as a precursor for chemical additives and in the sensor industry due to its unique spectral properties. Additionally, it is used in the semiconductor industry for certain fabrication processes.

When handling 2-Chloro-4-fluoro-5-nitrophenol (CAS: 84478-75-1), it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a laboratory coat. Handle in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly washed down. Always consult the Safety Data Sheet (SDS) for detailed emergency response procedures.