3-{4-[4-(Chlorosulfonyl)phenyl]-5-methyl-1,2-oxazol-3-yl}benzenesulfonyl chloride(CAS: 1373038-63-1)

3-{4-[4-(Chlorosulfonyl)phenyl]-5-methyl-1,2-oxazol-3-yl}benzenesulfonyl chloride is a crystalline solid with a molecular weight of approximately 522.04 g/mol. Its solubility in water is very low, making it suitable for applications requiring high purity. Chemically, it is highly reactive, particularly towards nucleophiles and bases, which can lead to coupling reactions and other transformations in synthetic chemistry.

3-{4-[4-(Chlorosulfonyl)phenyl]-5-methyl-1,2-oxazol-3-yl}benzenesulfonyl chloride is synthesized through a multi-step process, often involving the condensation of a 4-chlorosulfonylphenyl derivative with a 5-methyl-1,2-oxazol-3-carboxylic acid compound. The reaction typically requires mild to moderate temperatures and is catalyzed by common reagents like sulfuric acid. The overall yield is generally between 60-80%, depending on the purity of the starting materials and the optimization of reaction conditions.

3-{4-[4-(Chlorosulfonyl)phenyl]-5-methyl-1,2-oxazol-3-yl}benzenesulfonyl chloride finds applications in the pharmaceutical industry for the synthesis of complex molecules and intermediates. It is also used in polymer chemistry, where its reactive properties can be harnessed for functionalization and cross-linking. Additionally, this compound is employed in the development of sensors and semiconductors due to its unique chemical reactivity and stability.

When handling 3-{4-[4-(Chlorosulfonyl)phenyl]-5-methyl-1,2-oxazol-3-yl}benzenesulfonyl chloride, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work must be conducted in a well-ventilated area or a fume hood to minimize exposure to chlorosulfonyl groups. Spills should be cleaned up using appropriate absorbent materials and disposed of in accordance with local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.