(Z)-Roxithromycin(CAS: 134931-00-3)

(Z)-Roxithromycin is a semi-synthetic macrolide antibiotic with a molecular weight of approximately 869.9 g/mol. It is a white to off-white crystalline powder. Soluble in methanol, ethanol, and acetone but virtually insoluble in water. It shows moderate reactivity towards basic conditions and is stable under acidic conditions.

(Z)-Roxithromycin is synthesized via a semi-synthetic route from erythromycin, with key steps involving azalide formation and modification of the macrolide ring. The synthesis typically requires catalysts such as platinum(II) tetraacetate, and yields around 70-80%. The reaction is selective and environmentally friendly.

(Z)-Roxithromycin is primarily used in the pharmaceutical industry for treating bacterial infections. It is also used in veterinary medicine and can be found in some animal health products. Additionally, it has applications in research and development for studying antibiotic resistance.

When handling (Z)-Roxithromycin, use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or fume hood. Store in a cool, dry place away from direct sunlight. In case of spills, clean up immediately using appropriate procedures and consult the Safety Data Sheet (SDS) for detailed instructions.