(R,R)-Et-Duphos-Rh(CAS: 228121-39-9)

(R,R)-Et-Duphos-Rh is a chiral rhodium complex with a crystalline form and a molecular weight of approximately 500 g/mol. It has limited water solubility and exhibits high reactivity in catalytic processes, making it suitable for asymmetric synthesis. The complex is known for its stability in air and light, but should be handled under inert conditions to preserve its reactivity.

(R,R)-Et-Duphos-Rh is synthesized using rhodium acetate and a chiral ligand. The synthetic route involves the coordination of the ligand to the rhodium center, followed by the exchange of the acetate ligand with a more reactive one, such as a phosphine. The process typically yields a high enantiomeric excess (ee) and is performed under inert conditions to ensure reactivity and selectivity.

(R,R)-Et-Duphos-Rh is primarily used in the pharmaceutical industry for the synthesis of chiral compounds, which are essential for drug development. It is also applied in the production of chiral monomers for polymer synthesis and in the development of chiral sensors and semiconductors, where its catalytic and reactivity properties are highly valued.

When handling (R,R)-Et-Duphos-Rh, it should be done under a fume hood to avoid inhalation and contact with skin and eyes. Personal protective equipment (PPE) including gloves, safety goggles, and a lab coat is required. Spills should be cleaned up immediately with appropriate absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.