How is (R,R)-Et-Duphos-Rh (CAS: 228121-39-9) typically synthesized?

(R,R)-Et-Duphos-Rh is synthesized using rhodium acetate and a chiral ligand. The synthetic route involves the coordination of the ligand to the rhodium center, followed by the exchange of the acetate ligand with a more reactive one, such as a phosphine. The process typically yields a high enantiomeric excess (ee) and is performed under inert conditions to ensure reactivity and selectivity.