(E)-N-(4-Amino-1-hydroxybutylidene)-L-histidine(CAS: 3650-73-5)

(E)-N-(4-Amino-1-hydroxybutylidene)-L-histidine is a white to off-white crystalline powder with a molecular weight of approximately 287.38 g/mol. It has a slight solubility in water and is less soluble in organic solvents. This compound is relatively stable under normal conditions but may react with strong acids or bases. It is not flammable and has a high melting point, making it suitable for various applications in chemistry and pharmaceuticals.

(E)-N-(4-Amino-1-hydroxybutylidene)-L-histidine can be synthesized by a multi-step process involving the condensation of 4-amino-1-hydroxybutanone with L-histidine. The reaction typically requires a Lewis acid catalyst and proceeds with high selectivity. The yield is usually around 80-90%, and the purity can be enhanced through recrystallization.

(E)-N-(4-Amino-1-hydroxybutylidene)-L-histidine finds applications in various industries, particularly in pharmaceuticals for its potential as a histidine derivative with specific biological functions. It is also used in the formulation of certain polymers and as a component in sensors due to its unique chemical properties.

When handling (E)-N-(4-Amino-1-hydroxybutylidene)-L-histidine, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be carried out in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up carefully using appropriate absorbents, and the Material Safety Data Sheet (MSDS) should be consulted for specific procedures and safety information.