2-Fluoro-3-iodo-5-methylpyridine(CAS: 153034-78-7)

2-Fluoro-3-iodo-5-methylpyridine is a crystalline solid with a molecular weight of approximately 268.02 g/mol. It has limited water solubility and is soluble in organic solvents like ethanol and dichloromethane. This compound is known for its low reactivity under normal conditions but can be sensitive to air and moisture. It is used in various synthetic applications and should be handled in a fume hood.

2-Fluoro-3-iodo-5-methylpyridine can be synthesized via the iodination of 2-fluoro-5-methylpyridine using N-iodosuccinimide (NIS) as an oxidizing agent in the presence of a base like sodium hydride. The reaction typically yields high selectivity and good to excellent yields, depending on the conditions.

2-Fluoro-3-iodo-5-methylpyridine is primarily used in pharmaceutical research, where it serves as a key intermediate in the synthesis of various drugs. It is also used in the development of materials for sensors and semiconductors due to its unique electronic properties.

When handling 2-Fluoro-3-iodo-5-methylpyridine, it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a dry, well-ventilated area, and all reactions should be performed in a fume hood. In case of a spill, neutralize the area with water and notify safety personnel. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.