Ethyl 6-chloronicotinate(CAS: 49608-01-7)

Ethyl 6-chloronicotinate (CAS: 49608-01-7) is a white crystalline solid with a molecular weight of approximately 182.63 g/mol. It is slightly soluble in water and highly soluble in organic solvents. The compound is moderately reactive, particularly towards nucleophiles and bases. It is used in pharmaceuticals and as a reagent in organic synthesis.

Ethyl 6-chloronicotinate is typically synthesized by the nucleophilic substitution of ethyl isonicotinate with chloride ions. Common methods include using thionyl chloride or phosphorus oxychloride as the chlorinating agent. The reaction yields a high purity product with good selectivity and yield, making it a versatile starting material in organic chemistry.

Ethyl 6-chloronicotinate (CAS: 49608-01-7) is primarily used in the pharmaceutical industry for synthesizing various drugs. It is also employed in the polymer industry as a stabilizer and in the production of sensors and semiconductors due to its chemical reactivity.

When handling Ethyl 6-chloronicotinate (CAS: 49608-01-7), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Store it in a well-ventilated area and use a fume hood during handling. Spills should be cleaned up immediately, and the Safety Data Sheet (SDS) should be consulted for detailed instructions. This compound is slightly corrosive, so avoid contact with skin and eyes.