1-(Benzofuran-5-yl)propan-2-amine hydrochloride(CAS: 286834-80-8)

1-(Benzofuran-5-yl)propan-2-amine hydrochloride (CAS: 286834-80-8) is a white crystalline solid. It has a molecular weight of approximately 268.27 g/mol and a solubility in water of 15 mg/mL. It exhibits weak basic properties and is highly soluble in organic solvents like methanol and ethanol. The compound is stable under normal conditions but may degrade under acidic or oxidizing conditions. It is reactive with strong acids and bases, and its reactivity can be influenced by temperature and impurities.

1-(Benzofuran-5-yl)propan-2-amine hydrochloride is typically synthesized via a multi-step process. The starting material, benzofuran-5-amine, is reacted with propan-2-amine under basic conditions to form the corresponding amide. Subsequent acidification with hydrochloric acid converts the amide to the hydrochloride salt. The yield is around 75-80%, and the reaction is catalyzed by a mild base like triethylamine. The method is selective and reproducible.

1-(Benzofuran-5-yl)propan-2-amine hydrochloride (CAS: 286834-80-8) is used in pharmaceutical applications, particularly in the development of certain drug candidates. It is also utilized in the synthesis of organic semiconductors and in the preparation of materials for sensors due to its unique chemical properties. The compound's ability to form stable complexes and its reactivity make it valuable in these industries.

When handling 1-(Benzofuran-5-yl)propan-2-amine hydrochloride (CAS: 286834-80-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with care to avoid inhaling the powder. Follow standard safety procedures and consult the Safety Data Sheet (SDS) for further guidance. The compound is stable in dry conditions but should be stored in a cool, dry place away from strong acids and bases.