2,6-Dichloro-3-(tributylstannyl)pyrazine(CAS: 446285-70-7)

2,6-Dichloro-3-(tributylstannyl)pyrazine is a solid with a crystalline form. It has a molecular weight of approximately 464.4 g/mol and is poorly soluble in water. This compound is known for its reactivity towards nucleophiles and its stability under normal conditions. It is a potential precursor in organometallic chemistry.

2,6-Dichloro-3-(tributylstannyl)pyrazine can be synthesized using a Grignard reaction followed by a Stille coupling. The reaction typically involves a pyrazine derivative, chlorides, and tributyltin chloride in the presence of a palladium catalyst. The yield is around 70-80%, with high selectivity towards the desired product.

2,6-Dichloro-3-(tributylstannyl)pyrazine is used in the pharmaceutical industry for the development of new drugs, particularly in the synthesis of complex organic molecules. It may also find applications in polymer chemistry and as a precursor in semiconductor materials.

When handling 2,6-Dichloro-3-(tributylstannyl)pyrazine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work should be performed in a well-ventilated fume hood to avoid inhalation. In case of spill, contact a chemical spill response team and refer to the Safety Data Sheet (SDS) for detailed instructions.