3-(3-Nitrophenyl)pyridine(CAS: 4282-50-2)

3-(3-Nitrophenyl)pyridine is a crystalline solid with a molecular weight of approximately 220.08 g/mol. It has a low solubility in water but is soluble in common organic solvents like dichloromethane and ethanol. This compound is relatively stable but can decompose under strong reducing conditions. It shows moderate reactivity towards nucleophiles and electrophiles.

3-(3-Nitrophenyl)pyridine is typically synthesized via electrophilic aromatic substitution. The reaction involves the nitration of 3-pyridylbenzene using nitric acid and sulfuric acid as the nitrating reagents. The yield is usually around 70-80%, and the reaction is carried out under mild conditions to ensure selectivity.

3-(3-Nitrophenyl)pyridine finds applications in pharmaceuticals, where it serves as a precursor for the synthesis of dyes and pigments. It is also used in the production of certain sensors and semiconductors due to its unique electronic properties.

When handling 3-(3-Nitrophenyl)pyridine, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation. Spills should be immediately cleaned up with water and appropriate absorbents. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.