L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl-N~5~-(diaminomethylene)-L-ornithinamide(CAS: 197794-83-5)

L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl-N~5~-(diaminomethylene)-L-ornithinamide is a crystalline compound with a molecular weight of approximately 841.6 g/mol. It has a solubility of about 0.01 g/L in water at 25°C. The compound is moderately reactive, showing susceptibility to hydrolysis under basic conditions. It is stable in acidic environments. The compound is insoluble in common organic solvents like ethanol and acetonitrile.

L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl-N~5~-(diaminomethylene)-L-ornithinamide is typically synthesized through solid-phase peptide synthesis (SPPS). The process involves stepwise coupling of the amino acid building blocks, followed by deprotection and cleavage from the solid support. Commonly used coupling agents include HBTU and HOAt, with a high degree of selectivity and yield. The final step involves the addition of the N~5~-(diaminomethylene)-L-ornithinamide moiety.

L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl-N~5~-(diaminomethylene)-L-ornithinamide is primarily used in the pharmaceutical industry for the development of novel drugs, particularly those targeting specific protein-protein interactions. It is also explored in the sensor technology sector for its potential in biosensing applications.

When handling L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl-N~5~-(diaminomethylene)-L-ornithinamide (CAS: 197794-83-5), it is important to wear appropriate personal protective equipment (PPE) such as gloves, lab coat, and safety goggles. The compound should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up with appropriate absorbent material and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and disposal information.